(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

Base Information

Chemical Name:(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline
CAS No.:1421193-95-4
Molecular Formula:C₄₅H₄₇N₉O₉
Molecular Weight:857.923
Hs Code.:

Synonyms:(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

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Chemical Property of (4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

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Technology Process of (4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

There total 7 articles about (4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1421193-80-7
di(tert-butyl) [6-(benzyloxy)-9-(prop-2-yn-1-yl)-9H-purin-2-yl]imidodicarbonate

: 263847-08-1
(2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid

: 1421193-95-4
(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; In N,N-dimethyl-formamide; at 45 ℃; for 2h;
DOI:10.1002/hlca.201200557

Reference yield:

: 1384872-38-1
tert-butyl 6-(benzyloxy)-2-{[bis(tert-butoxy)carbonyl]amino}-9H-purine-9-carboxylate

: 1421193-95-4
(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / methanol; water / 1 h / 50 °C

2: potassium carbonate / N,N-dimethyl-formamide; toluene / 15 h / 20 °C

3: tetrakis(actonitrile)copper(I) hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 45 °C

With tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate; potassium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.201200557

Reference yield:

: 19916-73-5
2-Amino-6-benzyloxypurine

: 1421193-95-4
(4S)-4-[4-({6-(benzyloxy)-2-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}methyl)-1H-1,2,3-triazol-1-yl]-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / tetrahydrofuran / 15 h / 20 °C

2: sodium hydrogencarbonate / methanol; water / 1 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide; toluene / 15 h / 20 °C

4: tetrakis(actonitrile)copper(I) hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 45 °C

With dmap; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.201200557