1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide

Base Information

• Chemical Name: 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide
• CAS No.: 142613-79-4
• Molecular Formula: C₂₂H₂₂INO₃
• Molecular Weight: 475.326

Synonyms:1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide

Chemical Property of 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide

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Technology Process of 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide

There total 5 articles about 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzyl bromide (100-39-0) + 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid (2-iodo-phenyl)-amide (211116-49-3) → 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide (142613-79-4)

Guidance literature:

With sodium hydride;

DOI:10.1021/ja980786p

Reference yield:

2-iodophenylamine (615-43-0) → 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide (142613-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 5 h / Heating

2: 81 percent / NaH

With sodium hydride; triethylamine; In tetrahydrofuran;

DOI:10.1021/ja980786p

Reference yield:

1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylic acid (92525-59-2) → 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide (142613-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, 2.) SOCl₂ / 1.) THF, RT, 2 h, 2.) THF, RT, 2.5 h

2: Et₃N / tetrahydrofuran / 5 h / Heating

3: 81 percent / NaH

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran;

DOI:10.1021/ja980786p

upstream raw materials:

benzyl bromide

1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid (2-iodo-phenyl)-amide

2-iodophenylamine

1,4-dioxaspiro[4.5]dec-7-ene-8-carbaldehyde

Downstream raw materials:

(S)-(-)-1'-benzyl-1',2'-dihydro-2'-oxospiro[1,4-dioxaspiro[4.5]dec-6-ene8,3'-3'H-indole]

(R)-(+)-1'-benzyl-1',2'-dihydro-2'-oxospiro[1,4-dioxaspiro[4.5]dec-6-ene-8,3'-3'H-indole]

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