5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

Base Information

Chemical Name:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide
CAS No.:1403590-60-2
Molecular Formula:C₂₂H₂₈ClN₃O₃
Molecular Weight:417.936
Hs Code.:

Synonyms:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

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Chemical Property of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

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Technology Process of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

There total 3 articles about 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403595-52-7
C₁₄H₁₈ClNO₃

: 1403590-60-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₄H₁₈ClNO₃; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1403590-60-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 0.17 h / -10 °C

1.2: 0.5 h / -10 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

4.1: acetic acid / methanol / 3 h / 20 °C

5.1: caesium carbonate / acetonitrile / 13 h / 80 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.2: pH 4 - 6

7.1: dimethyl sulfoxide / 0.25 h / 20 °C

With sulfuric acid; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 154257-81-5
5-chloro-2-methyl-3-nitrobenzoic acid

: 1403590-60-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

3.1: acetic acid / methanol / 3 h / 20 °C

4.1: caesium carbonate / acetonitrile / 13 h / 80 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;