3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole

Base Information

• Chemical Name: 3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole
• CAS No.: 769957-34-8
• Molecular Formula: C₂₉H₃₂N₂O₃
• Molecular Weight: 456.585

Synonyms:3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole

Chemical Property of 3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole

There total 4 articles about 3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone (882045-34-3) → 3-O-benzylestra-1,3,5(10)-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole (769957-34-8)

Guidance literature:

3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone; With hydrazine hydrate; In ethanol; dichloromethane; for 0.25h; Heating;

With toluene-4-sulfonic acid; In ethanol; for 0.0833333h; Heating;

DOI:10.1021/jm050348a

Reference yield:

Estrone (53-16-7) → 3-O-benzylestra-1,3,5(10)-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole (769957-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

2.1: 99 percent / t-BuOK / toluene / 20 °C

3.1: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.25 h / Heating

3.2: 79 percent / p-toluenesulfonic acid monohydrate / ethanol / 0.08 h / Heating

With potassium tert-butylate; sodium hydride; hydrazine hydrate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm050348a

Reference yield:

3-benzyloxyestra-1,3,5(10)-trien-17-one (858-98-0) → 3-O-benzylestra-1,3,5(10)-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole (769957-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / t-BuOK / toluene / 20 °C

2.1: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.25 h / Heating

2.2: 79 percent / p-toluenesulfonic acid monohydrate / ethanol / 0.08 h / Heating

With potassium tert-butylate; hydrazine hydrate; In ethanol; dichloromethane; toluene;

DOI:10.1021/jm050348a

upstream raw materials:

3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone

Estrone

3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

benzyl bromide

Downstream raw materials:

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c][5'-(furan-2''-ylmethyl)carbamoyl]pyrazole

GMA₀₂₀₃₈-6

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid)pyrazole

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-hydroxymethyl)pyrazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 769957-34-8 3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid ethyl ester)pyrazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send