3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone

Base Information

• Chemical Name: 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone
• CAS No.: 882045-34-3
• Molecular Formula: C₂₉H₃₂O₅
• Molecular Weight: 460.57

Synonyms:3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone

Chemical Property of 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone

Chemical Property:

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Technology Process of 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone

There total 3 articles about 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-benzyloxyestra-1,3,5(10)-trien-17-one (858-98-0) + oxalic acid diethyl ester (95-92-1) → 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone (882045-34-3)

Guidance literature:

With potassium tert-butylate; In toluene; at 20 ℃;

DOI:10.1021/jm050348a

Reference yield:

Estrone (53-16-7) → 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone (882045-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 99 percent / t-BuOK / toluene / 20 °C

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm050348a

Reference yield:

benzyl bromide (100-39-0) → 3-O-benzyl-16-(1'-hydroxy-2'-carboxylic acid ethyl ester-ethylidene)estrone (882045-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 99 percent / t-BuOK / toluene / 20 °C

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm050348a

upstream raw materials:

3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

oxalic acid diethyl ester

Estrone

benzyl bromide

Downstream raw materials:

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-hydroxymethyl)pyrazole

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c](5'-carboxylic acid)pyrazole

GMA₀₂₀₃₈-6

3-O-benzylestra-1,3,5⁽¹⁰⁾-triene[17,16-c][5'-(furan-2''-ylmethyl)carbamoyl]pyrazole

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