dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate

Base Information

• Chemical Name: dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate
• CAS No.: 1010692-92-8
• Molecular Formula: C₁₄H₂₄NO₄PS
• Molecular Weight: 333.389

Synonyms:dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate

Chemical Property of dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate

Chemical Property:

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Technology Process of dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate

There total 2 articles about dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl phosphite (96-36-6,868-85-9) + (S)-2-methyl-N-(4-methylbenzylidene)propane-2-sulfinamide → dimethyl ((R)-{[(S)-tert-butanesulfinyl]amino}(p-tolyl)methyl)phosphonate + dimethyl [(SS,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate (1010692-92-8)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h; Overall yield = 86 %; Overall yield = 143 mg; diastereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1339712

Reference yield:

(E)-(S)-2-methyl-propane-2-sulfinic acid 1-p-tolyl-methylideneamide (856562-52-2) + Dimethyl phosphite (868-85-9) → dimethyl ((R)-{[(S)-tert-butanesulfinyl]amino}(p-tolyl)methyl)phosphonate + dimethyl [(SS,R)-(+)-(tert-butylsulfinylamino)(4-methylphenyl)methyl]phosphonate (1010692-92-8)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1055/s-2007-990872

upstream raw materials:

(E)-(S)-2-methyl-propane-2-sulfinic acid 1-p-tolyl-methylideneamide

Dimethyl phosphite

methyl phosphite

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