34813-49-5

Basic information

• Product Name: TERT-BUTYLSULFONAMIDE
• Synonyms: TERT-BUTYLSULFONAMIDE;TERT-BUTYLSULPHONAMIDE;2-METHYL-PROPANE-2-SULFONIC ACID AMIDE;2-Methylpropane-2-sulfonaMide;2-Propanesulfonamide, 2-methyl-;tert-Butylsulfonamide
• CAS NO: 34813-49-5
• Molecular Formula: C₄H₁₁NO₂S
• Molecular Weight: 137.2
• Product Categories: Sulphur Derivatives
• Mol File: 34813-49-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 166.0 to 170.0 °C
• Boiling Point: 223.1ºC at 760 mmHg
• Flash Point: 88.7ºC
• Appearance: /
• Density: 1.149g/cm3
• Vapor Pressure: 0.0982mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 10.93±0.60(Predicted)
• CAS DataBase Reference: TERT-BUTYLSULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYLSULFONAMIDE(34813-49-5)
• EPA Substance Registry System: TERT-BUTYLSULFONAMIDE(34813-49-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 34813-49-5(Hazardous Substances Data)

Usage

General Description

Tert-Butylsulfonamide, often abbreviated as TBSA, is an organic chemical compound categorized under tertiary alkyl sulfonamides. Synthesized through the reaction of tert-butylamine with sulfuryl chloride, it exhibits a water solubility of approximately 1000 mg/L and a high boiling point of 128 degrees Celsius. It’s extensively incorporated in chemical manufacturing processes, especially in the synthesis of pharmaceuticals, as an intermediate, and in rubber production as a flame retardant. The compound is deemed hazardous if ingested, inhaled, or in contact with skin, and it can also pose environmental risks if not handled properly.

InChI:InChI=1/C4H11NO2S/c1-4(2,3)8(5,6)7/h1-3H3,(H2,5,6,7)

Upstream product

• 31562-43-3 tert-butylsulfinyl chloride 
• 146374-27-8 S-tert-butylsulfinimide 
• 10490-22-9 tert-butylsulfonyl chloride 
• 677-22-5 tert-butylmagnesium chloride 
• 1730-25-2 allylmagnesium bromide 
• 75-64-9 tert-butylamine 
• 110955-57-2 2-Methyl-propane-2-sulfonic acid isopropylidene-amide 
• 14094-12-3 tert-butyl methyl sulfone 

Downstream Products

• 881840-76-2 2-methyl-propane-2-sulfonic acid (2-hydroxy-5-phenyl-hex-5-enyl)-amide 
• 1001615-27-5 2-methyl-propane-2-sulfonic acid (4-cyclohexa-1,4-dienyl-2-hydroxy-butyl)-amide 
• 881840-71-7 2-methyl-propane-2-sulfonic acid (2-hydroxy-3,3-diphenyl-hex-5-enyl)-amide 
• 1114547-83-9 N-(tert-butylsulfonyl)benzamide 
• 1126682-83-4 N-benzhydryl-2-methylpropane-2-sulfonamide 
• 1443536-92-2 (R)-N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1365611-46-6 C₁₃H₂₇N₃O₃S 
• 1305205-30-4 2-methyl-N-(p-tolyl)propane-2-sulfonamide 
• 1217335-26-6 5-(3-(tert-butylsulfonylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide 
• 1322084-19-4 N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide 

Relevant articles and documents

Preparation of (2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester

Synthesis of (2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester from tert-butylsulfonamide, thionyl chloride and ethyl glyoxylate is described. The N-tert-butylsulfonyl imino ester has served as a substitute of the corresponding N-toluenesulfonyl imino ester in allylation reactions.

Fe(III)/ l -Valine-Catalyzed One-Pot Synthesis of N -Sulfinyl- and N -Sulfonylimines via Oxidative Cascade Reaction of Alcohols with Sulfinamides or Sulfonamides

An efficient Fe(III), l -valine, and 4-OH-TEMPO catalytic system was found for the oxidation of alcohols followed by condensation with sulfinamide or sulfonamide in one pot for the synthesis of N -sulfinyl- and N- sulfonylimines compounds under mild conditions. This transformation accommodates a variety of substrates, shows high functional-group tolerance, and affords the corresponding products in good to excellent yields.

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.