[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol

Base Information

• Chemical Name: [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol
• CAS No.: 189166-72-1
• Molecular Formula: C₄₁H₅₈O₄Si₂
• Molecular Weight: 671.08

Synonyms:[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol

Chemical Property of [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol

There total 4 articles about [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene (150966-64-6) + 2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-benzaldehyde (189166-71-0) → [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol (189166-72-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 to 25 deg C, 2.) 0 deg C, 0.5 h;

DOI:10.1002/chem.19970030311

Reference yield:

3-methoxy-o-xylene-α,α'-diol (90047-52-2) → [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol (189166-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 33 percent / imidazole / CH₂Cl₂ / 1 h / 0 °C

2: 86 percent / PDC, molecular sieves 4 Angstroem / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

3: 85 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 to 25 deg C, 2.) 0 deg C, 0.5 h

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/chem.19970030311

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol (189166-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 33 percent / imidazole / CH₂Cl₂ / 1 h / 0 °C

2: 86 percent / PDC, molecular sieves 4 Angstroem / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

3: 85 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 to 25 deg C, 2.) 0 deg C, 0.5 h

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/chem.19970030311

upstream raw materials:

2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene

2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-benzaldehyde

3-methoxy-o-xylene-α,α'-diol

tert-butylchlorodiphenylsilane

Downstream raw materials:

Benzoic acid (1S,2S,9R,10R,13S)-9,10-diacetoxy-13-((2R,3S)-3-benzoylamino-3-phenyl-2-triethylsilanyloxy-propionyloxy)-1-hydroxy-4-methoxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester

Benzoic acid (1R,2R,9S,10S,13R)-9,10-diacetoxy-13-((2R,3S)-3-benzoylamino-3-phenyl-2-triethylsilanyloxy-propionyloxy)-1-hydroxy-4-methoxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 189166-72-1 [5-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-phenyl]-methanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send