150966-64-6

Basic information

• Product Name: 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene
• Synonyms: 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene
• CAS NO: 150966-64-6
• Molecular Weight: 562.933
• Mol File: 150966-64-6.mol

Chemical Properties

• CAS DataBase Reference: 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene(150966-64-6)
• EPA Substance Registry System: 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene(150966-64-6)

Safety Data

• Hazardous Substances Data: 150966-64-6(Hazardous Substances Data)

Upstream product

• 17773-75-0 2-carbethoxy-1,1,3-trimethyl-1,3-butadiene 
• 144066-82-0 Acetic acid 2-isopropenyl-3-methyl-but-2-enyl ester 
• 144066-83-1 Acetic acid 5-chloro-5-cyano-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 52385-60-1 (3-methyl-2-methylethenyl)-2-buten-1-ol 
• 99978-27-5 2-(α-hydroxy-isopropyl)-3-methyl-crotonic acid ethyl ester 
• 35044-52-1 ethyl 2-acetyl-3-methylbut-2-enoate 
• 150966-81-7 6,6,8-trimethyl-1,4-dioxaspiro[4.5]decan-7-one hydrazone 
• 150966-58-8 5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene 
• 14782-52-6 ethylene glycole monoacetal of 2,2-dimethylcyclohexane-1,3-dione 
• 141665-47-6 5,5-(ethylenedioxy)-2,6,6-trimethyl-1-cyclohexenecarboxaldehyde 
• 114198-58-2 3,3-(ethylenedioxy)-2,2,6-trimethyl-1-cyclohexanone 
• 152328-14-8 3-Hydroxymethyl-2,2,4-trimethyl-cyclohex-3-enone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 562-13-0 2,2-dimethyl-1,3-cyclohexanedione 

Downstream Products

• 595568-54-0 2-(tert-butyldimethylsiloxymethyl)-4-hydroxymethyl-1,3,3-trimethyl-cyclohexa-1,4-diene 
• 595568-56-2 (4S)-2-(tert-butyldimethylsiloxymethyl)-4-hydroxy-4-(hydroxymethyl)-1,3,3-trimethyl-cyclohex-1-ene 
• 595568-60-8 (5S)-3-(tert-butyldimethylsiloxymethyl)-5-hydroxy-5-benzoyloxymethyl-2,4,4-trimethyl-cyclohex-2-en-1-one 
• 595568-59-5 (4S)-2-(tert-butyldimethylsiloxymethyl)-4,6-dihydroxy-4-benzoyloxymethyl-1,3,3-trimethyl-cyclohex-1-ene 
• 595568-53-9 (4S,5R)-2-(tert-butyldimethylsiloxymethyl)-4,6-dihydroxy-4-benzoyloxymethyl-1,3,3-trimethyl-cyclohex-1-ene 
• 155192-69-1 Benzoic acid (1S,2S,9R,10R)-9,10-diacetoxy-1-hydroxy-12,15,15-trimethyl-13-oxo-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 
• 155192-70-4 Benzoic acid (1S,2S,9R,10R,13S)-9,10-diacetoxy-1,13-dihydroxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 
• 155192-77-1 Benzoic acid (1S,2S,9R,10R)-9,10-diacetoxy-1-hydroxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 
• 155192-68-0 Benzoic acid (1S,2S,9R,10R)-1,9,10-trihydroxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 
• 155192-71-5 Benzoic acid (1S,2S,9R,10R,13S)-9,10-diacetoxy-13-((2R,3S)-3-benzoylamino-3-phenyl-2-triethylsilanyloxy-propionyloxy)-1-hydroxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 
• 175275-04-4 Benzoic acid (1R,2R,9S,10S,13R)-9,10-diacetoxy-13-((2R,3S)-3-benzoylamino-3-phenyl-2-triethylsilanyloxy-propionyloxy)-1-hydroxy-12,15,15-trimethyl-tricyclo[9.3.1.0^3,8]pentadeca-3⁽⁸⁾,4,6,11-tetraen-2-yl ester 

Relevant articles and documents

A concise enantioselective synthesis of a fully oxygen substituted ring A taxol precursor

A concise synthesis of the oxygen substituted ring A compound 2 found in Taxol 1a and Taxotere 1b starting from 2,2-dimethylcyclohexane-1,3-dione and proceeding via the key intermediates 8 and 11, is described. The absolute configuration of 2 was established from an X-ray crystal structure determination of a 4-bromophenylbenzoate derivative, viz. 15.

Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system

A method for the formation of Taxol's ABC ring system has been developed. General methods for the synthesis of versatile synthons for Taxol's A ring (8) and C ring (55) are presented. A model study using a simplified C ring synthon (17) confirmed the viability of the sequential Shapiro-McMurry strategy for formation of Taxol's B ring. Careful exploration of the chemistry of various A-B ring conjugates allowed the development of a successful method for formation of the B ring in a more functionalized system.