3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid
CAS No.:1455087-69-0
Molecular Formula:C₂₂H₁₈ClN₃O₅
Molecular Weight:439.855
Hs Code.:

Synonyms:3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Chemical Property:

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Technology Process of 3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

There total 3 articles about 3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455092-35-9
ethyl 3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoate

: 1455087-69-0
3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 5h;

Reference yield:

: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

: 1455087-69-0
3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: ethanol / 1.5 h / 150 °C / Microwave irradiation

3: sodium hydroxide / methanol; water / 5 h / 20 °C

With hydrogen; sodium hydroxide; In methanol; ethanol; water;

Reference yield:

: methyl 7-(2-chlorophenoxy)-4-hydroxy-1-iodoisoquinoline-3-carboxylate

: 1455087-69-0
3-(7-(2-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 0.12 h / 120 °C

2: ethanol / 1.5 h / 150 °C / Microwave irradiation

3: sodium hydroxide / methanol; water / 5 h / 20 °C

With sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide;