p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside

Base Information

• Chemical Name: p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside
• CAS No.: 949489-27-4
• Molecular Formula: C₄₂H₄₄O₆S
• Molecular Weight: 676.874
• Mol file: 949489-27-4.mol

Synonyms:p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside

Chemical Property of p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside

There total 5 articles about p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-tolyl 3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside (949489-26-3) + benzyl bromide (100-39-0) → p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside (949489-27-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo070585g

Reference yield:

p-methylphenyl-1-thio-β-D-galactopyranoside (1152-39-2,28244-98-6,121523-95-3,131488-68-1) → p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside (949489-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dibutyltin oxide / methanol / 2 h / Heating

1.2: 55 percent / CsF / methanol; dimethylformamide / 48 h / 50 °C

2.1: 80 percent / NaH / dimethylformamide / 20 °C

With sodium hydride; di(n-butyl)tin oxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo070585g

Reference yield:

4-methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside (28244-94-2,28244-99-7,86782-41-4,131488-65-8) → p-tolyl 2,4,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside (949489-27-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / NaOMe / CH₂Cl₂; methanol / 6 h / 20 °C

2.1: dibutyltin oxide / methanol / 2 h / Heating

2.2: 55 percent / CsF / methanol; dimethylformamide / 48 h / 50 °C

3.1: 80 percent / NaH / dimethylformamide / 20 °C

With sodium methylate; sodium hydride; di(n-butyl)tin oxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo070585g

upstream raw materials:

p-tolyl 3-O-(p-methoxybenzyl)-1-thio-β-D-galactopyranoside

benzyl bromide

p-methylphenyl-1-thio-β-D-galactopyranoside

4-methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside

Downstream raw materials:

p-tolyl 2,4,6-tri-O-benzyl-1-thio-β-D-galactopyranoside

C₉₄H₁₀₂O₁₇

C₆₂H₆₆O₁₁

C₆₂H₆₆O₁₁