cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine

Base Information

• Chemical Name: cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine
• CAS No.: 1041850-65-0
• Molecular Formula: C₂₁H₂₃FN₄S
• Molecular Weight: 382.505

Synonyms:cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine

Chemical Property of cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine

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Technology Process of cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine

There total 2 articles about cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.7%

cyclohexylamine (108-91-8,157973-60-9) + 2-fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridine (549505-59-1) → cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine (1041850-65-0)

Guidance literature:

at 160 ℃; for 24h; Autoclave;

DOI:10.1021/jm101623p

Reference yield:

4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione (581098-38-6) → cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine (1041850-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol

2: 24 h / 160 °C / Autoclave

With potassium carbonate; In methanol;

DOI:10.1021/jm101623p

Reference yield: 56.5%

cyclohexyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine (1041850-65-0) → N-cyclohexyl-4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)pyridin-2-amine (1289617-17-9)

Guidance literature:

With potassium peroxomonosulfate; In tetrahydrofuran; water; at 0 ℃; for 2h;

DOI:10.1021/jm101623p

upstream raw materials:

cyclohexylamine

2-fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridine

4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

Downstream raw materials:

N-cyclohexyl-4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)pyridin-2-amine

N-cyclohexyl-4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)pyridin-2-amine

N-cyclohexyl-4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)pyridin-2-amine

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