(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Base Information

Chemical Name:(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol
CAS No.:1142234-83-0
Molecular Formula:C₂₂H₂₇FO₂
Molecular Weight:342.454
Hs Code.:

Synonyms:(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

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Chemical Property of (2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Chemical Property:

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Technology Process of (2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

There total 13 articles about (2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1142226-06-9
(2-(2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

: 1142234-82-9
(2-((1R)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

: 1142234-83-0
(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: With CHIRALCEL OD; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1193-47-1
2,2-dimethyl-cyclohexanone

: 1142234-82-9
(2-((1R)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

: 1142234-83-0
(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

1.2: -78 - 23 °C

2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 3.5 h / 50 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 23 - 90 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 0 °C

5.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C

6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 96 h / 23 °C

7.1: pyridinium p-toluenesulfonate / methanol / 4.5 h

8.1: Chiracel-OD / hexane; isopropyl alcohol / Resolution of racemate

With dmap; lithium aluminium tetrahydride; potassium phenolate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 14719-83-6
methyl 3-nitro-4-chlorobenzoate

: 1142234-82-9
(2-((1R)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

: 1142234-83-0
(2-((1S)-2,2-dimethylcyclohexyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 23 - 90 °C

2.1: acetic acid; tin(ll) chloride / 1,2-dimethoxyethane; ethanol / 17 h / 23 - 60 °C

3.1: sulfuric acid / 1,2-dimethoxyethane; water / 23 °C

3.2: 0 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 23 - 90 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 0 °C

6.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C

7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 96 h / 23 °C

8.1: pyridinium p-toluenesulfonate / methanol / 4.5 h

9.1: Chiracel-OD / hexane; isopropyl alcohol / Resolution of racemate

With dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; acetic acid; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;