Technology Process of C12H11N3O3
There total 4 articles about C12H11N3O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bromocyane; methylamine;
With
potassium carbonate;
In
tetrahydrofuran;
at -68 - -65 ℃;
for 2h;
Inert atmosphere;
C10H8ClNO3;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at -65 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / methanol / 20 °C
1.2: pH 7
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
2.2: 0.5 h
3.1: potassium carbonate / tetrahydrofuran / 2 h / -68 - -65 °C / Inert atmosphere
3.2: 4 h / -65 °C
With
oxalyl dichloride; water; potassium carbonate; sodium hydroxide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
1.2: 18.5 h / 20 °C
2.1: sodium hydroxide; water / methanol / 20 °C
2.2: pH 7
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
3.2: 0.5 h
4.1: potassium carbonate / tetrahydrofuran / 2 h / -68 - -65 °C / Inert atmosphere
4.2: 4 h / -65 °C
With
n-butyllithium; oxalyl dichloride; water; potassium carbonate; sodium hydroxide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
