9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

Base Information

Chemical Name:9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester
CAS No.:637003-75-9
Molecular Formula:C₃₃H₅₃Cl₃O₈Si
Molecular Weight:712.224
Hs Code.:

Synonyms:9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

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Chemical Property of 9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

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Technology Process of 9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

There total 7 articles about 9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 994-30-9
triethylsilyl chloride

: 637003-55-5
9-benzyloxy-3-hydroxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)nonanoic acid tert-butyl ester

: 637003-75-9
9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

Guidance literature:: With 1H-imidazole;
DOI:10.1002/anie.200352361

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 637003-75-9
9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / diethyl ether / 0.5 h / -78 °C

1.2: 80 percent / diethyl ether / 1 h

2.1: 74 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

3.1: 80 percent / H₂; (R)-RuBINAP; HCl / methanol / 17 h / 62057.8 Torr

4.1: 51 percent / imidazole / dimethylformamide / 3 h / 0 °C

With 1H-imidazole; hydrogenchloride; (R)-RuBINAP; hydrogen; Dess-Martin periodane; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja046992g

Reference yield:

: 637003-53-3
9-benzyloxy-4,4,6,8-tetramethyl-3,5-dioxo-7-(2,2,2-trichloroethoxycarbonyloxy)nonanoic acid tert-butyl ester

: 637003-75-9
9-benzyloxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloroethoxycarbonyloxy)-3-(triethylsilanyloxy)nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / H₂; (R)-RuBINAP; HCl / methanol / 17 h / 62057.8 Torr

2: 51 percent / imidazole / dimethylformamide / 3 h / 0 °C

With 1H-imidazole; hydrogenchloride; (R)-RuBINAP; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja046992g