Technology Process of 6-(benzyloxy)-8-bromo-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid
There total 6 articles about 6-(benzyloxy)-8-bromo-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-(benzyloxy)-8-bromo-[1,2,4]triazolo[1,5-a]pyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -78 ℃;
for 1h;
carbon dioxide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
for 0.5h;
Cooling;
DOI:10.1021/acsmedchemlett.7b00404
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / toluene / 2.5 h / Reflux; Enzymatic reaction
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 48 h / Reflux
4.1: N,N-dimethyl-formamide / 0.25 h / 130 °C
4.2: 20 °C / Cooling with ice
5.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C
5.2: 0.5 h / Cooling
With
hydroxylamine hydrochloride; sodium hydride; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; n-heptane; ethylbenzene; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/acsmedchemlett.7b00404
