(R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine

Base Information

• Chemical Name: (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine
• CAS No.: 1000693-83-3
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397
• Mol file: 1000693-83-3.mol

Synonyms:(R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine

Chemical Property of (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine

There total 2 articles about (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate (155396-71-7) → (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine (1000693-83-3) + (S)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine (1000693-94-6)

Guidance literature:

With 4 A molecular sieve; potassium carbonate; {rhodium(acetylacetonate)(cis-cyclooctene)2}; In 1,4-dioxane; triethylamine; at 70 ℃; for 20h; Title compound not separated from byproducts.;

DOI:10.1021/ol702045w

Reference yield:

phenylboronic acid (98-80-6) + tert-butyl (4-methoxyphenyl)(phenylsulfonyl)methylcarbamate (741259-87-0) → (R)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine (1000693-83-3) + (S)-N-tert-butyloxycarbonyl-α-(4-methoxyphenyl)benzylamine (1000693-94-6)

Guidance literature:

With 2CF₃O₃S^(1-)*C₃₆H₃₀N₄O₂Pd⁽²⁺⁾; potassium carbonate; triethylamine; In 1,4-dioxane; at 65 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tet.2010.02.037

upstream raw materials:

4-methoxyphenylboronic acid

tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate

phenylboronic acid

tert-butyl (4-methoxyphenyl)(phenylsulfonyl)methylcarbamate