[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane
CAS No.:202062-73-5
Molecular Formula:C₅₁H₆₂O₇Si
Molecular Weight:815.135
Hs Code.:

Synonyms:[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

There total 10 articles about [(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 100-39-0
benzyl bromide

: 202062-72-4
(5S,6S,8S,9R,10R)-8-Benzyloxy-10-(tert-butyl-diphenyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-2,2,9-trimethyl-1,3-dioxa-spiro[4.5]decan-6-ol

: 202062-73-5
[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 202062-73-5
[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

3: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

4: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

5: 99 percent / nBu₄NI, KH / tetrahydrofuran / Ambient temperature

6: 84 percent / SeO₂, 70percent TBHP, salicylic acid / CH₂Cl₂ / 12 h / Ambient temperature

7: 82 percent / OsO₄, Me₃NO / acetone; H₂O / 36 h / Ambient temperature

8: 73 percent / CSA / CH₂Cl₂ / Ambient temperature

9: 93 percent / n-Bu₄NI, KH / tetrahydrofuran / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; osmium(VIII) oxide; lithium aluminium tetrahydride; selenium(IV) oxide; trimethylamine-N-oxide; 4 A molecular sieve; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; potassium hydride; salicylic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

: 202062-73-5
[(5S,6R,7R,8S,10S)-8,10-Bis-benzyloxy-7-(4-methoxy-benzyloxymethyl)-2,2,7-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

2: 99 percent / nBu₄NI, KH / tetrahydrofuran / Ambient temperature

3: 84 percent / SeO₂, 70percent TBHP, salicylic acid / CH₂Cl₂ / 12 h / Ambient temperature

4: 82 percent / OsO₄, Me₃NO / acetone; H₂O / 36 h / Ambient temperature

5: 73 percent / CSA / CH₂Cl₂ / Ambient temperature

6: 93 percent / n-Bu₄NI, KH / tetrahydrofuran / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; osmium(VIII) oxide; selenium(IV) oxide; trimethylamine-N-oxide; camphor-10-sulfonic acid; tetra-(n-butyl)ammonium iodide; potassium hydride; salicylic acid; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)10554-8