(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Base Information

Chemical Name:(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol
CAS No.:202062-65-5
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Chemical Property:

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Technology Process of (1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

There total 4 articles about (1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202062-60-0
(1R,2R,3S)-3-Hydroxy-2-(4-methoxy-benzyloxymethyl)-2-methyl-6-methylene-cyclohexanecarboxylic acid methyl ester

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1h; Yield given; 0 deg C up to RT;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

3: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

With lithium aluminium tetrahydride; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 202062-59-7
(Z)-5-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-3-methyl-oxiranyl]-3-trimethylsilanylmethyl-pent-2-enoic acid methyl ester

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

2: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

With lithium aluminium tetrahydride; 4 A molecular sieve; boron trifluoride diethyl etherate; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)10554-8