(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

Base Information

Chemical Name:(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one
CAS No.:77513-76-9
Molecular Formula:C₂₅H₃₈O₅
Molecular Weight:418.574
Hs Code.:

Synonyms:(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

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Chemical Property of (6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

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Technology Process of (6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

There total 7 articles about (6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 77514-11-5
(2S,3R)-3-Benzyloxy-2-methyl-2-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-cyclohexanone

: 77513-76-9
(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

Guidance literature:: With sodium acetate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Heating;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 77513-76-9
(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / TsOH / diethyl ether

2: 70 percent / MCPBA , NaOAc / CH₂Cl₂ / Heating

With sodium acetate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 77514-08-0
(6R,7S)-7-Benzyloxy-6-methyl-6-(4-methyl-pent-4-enyl)-1,4-dioxa-spiro[4.5]decane

: 77513-76-9
(6R,7S)-6-Benzyloxy-7-methyl-7-[4-methyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-oxepan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 9-BBN 2.) 30percent H₂O₂, 3N NaOH / 1.) THF

2: 99 percent / acetone , 2E-3N H₂SO₄

3: 90 percent / TsOH / diethyl ether

4: 70 percent / MCPBA , NaOAc / CH₂Cl₂ / Heating

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; sodium acetate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; acetone; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)81818-9