tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Base Information

Chemical Name:tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate
CAS No.:99197-93-0
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

Synonyms:tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

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Chemical Property of tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

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Technology Process of tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

There total 7 articles about tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 107-59-5
tert-Butyl chloroacetate

: 99197-92-9
3(S)-benzyloxycarbonylamino-2,3,4,5-tetrahydro-1,5-benzoxazepine-4-one

: 99197-93-0
tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

: 99197-93-0
tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / H₂ / 10 percent Pd-C / methanol / Ambient temperature

2: 61 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

3: 98 percent / 5 N HCl / ethyl acetate / 3 h / Ambient temperature

4: 92 percent / K₂CO₃ / ethyl acetate; H₂O / 1 h / 0 °C

5: 96 percent / K₂CO₃, KI / dimethylformamide / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide; palladium on activated charcoal; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 99197-93-0
tert-butyl (S)-3-benzyloxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, 4 h, r.t.

2: 84 percent / H₂ / 10 percent Pd-C / methanol / Ambient temperature

3: 61 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

4: 98 percent / 5 N HCl / ethyl acetate / 3 h / Ambient temperature

5: 92 percent / K₂CO₃ / ethyl acetate; H₂O / 1 h / 0 °C

6: 96 percent / K₂CO₃, KI / dimethylformamide / Ambient temperature

With hydrogenchloride; hydrogen; sodium hydride; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide; palladium on activated charcoal; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128