2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

Base Information

• Chemical Name: 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid
• CAS No.: 99197-79-2
• Molecular Formula: C₁₄H₂₀N₂O₅
• Molecular Weight: 296.323
• Mol file: 99197-79-2.mol

Synonyms:2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

Chemical Property of 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

There total 6 articles about 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid (99197-78-1) → 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid (99197-79-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

DOI:10.1021/acsmedchemlett.9b00108

Reference yield:

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) → 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid (99197-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, 4 h, r.t.

2: 84 percent / H₂ / 10 percent Pd-C / methanol / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.34.1128

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid (99197-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, 4 h, r.t.

2: 84 percent / H₂ / 10 percent Pd-C / methanol / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.34.1128

upstream raw materials:

(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

(S)-N-(tert-butoxycarbonyl)serine

ortho-nitrofluorobenzene

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)isoxazole-3-carboxamide

(S)-3-amino-5-methyl-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one hydrochloride

(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

(S)-N-((S)-5-((2-cyano-1-(2-cyanophenyl)-1H-indol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-2-(methylamino)propanamide trifluoroacetate