Technology Process of tert-butyl [(5R,6S,8S)-3-(2-methoxypropan-2-yl)-5-methyl-6-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]carbamate
There total 9 articles about tert-butyl [(5R,6S,8S)-3-(2-methoxypropan-2-yl)-5-methyl-6-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate;
In
acetonitrile;
at 70 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
2.1: sodium cyanoborohydride; ammonium acetate; acetic acid / methanol / 4 h / 60 °C
2.2: 1.5 h / 60 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 6.5 h / 760.05 Torr
3.2: 2.25 h / 2585.81 Torr
4.1: Lawessons reagent / toluene / 16 h / 40 °C
5.1: triethylamine; mercury dichloride / ethanol / 0.33 h
6.1: dipyridinium dichromate / acetonitrile / 1 h / 70 °C
With
Lawessons reagent; dipyridinium dichromate; ammonium acetate; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; mercury dichloride;
palladium 10% on activated carbon;
In
methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
2.1: sodium cyanoborohydride; ammonium acetate; acetic acid / methanol / 4 h / 60 °C
2.2: 1.5 h / 60 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 6.5 h / 760.05 Torr
3.2: 2.25 h / 2585.81 Torr
4.1: Lawessons reagent / toluene / 16 h / 40 °C
5.1: triethylamine; mercury dichloride / ethanol / 0.33 h
6.1: dipyridinium dichromate / acetonitrile / 1 h / 70 °C
With
Lawessons reagent; dipyridinium dichromate; ammonium acetate; hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; mercury dichloride;
palladium 10% on activated carbon;
In
methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
![tert-butyl {(3S,5S,6R)-2-[(2-hydroxy-3-methoxy-3-methylbutyl)imino]-6-methyl-5-phenylpiperidin-3-yl}carbamate](/Databaselist/images/loading.webp)
