8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

Base Information

Chemical Name:8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide
CAS No.:87120-69-2
Molecular Formula:C₁₉H₁₅ClFN₃O₃S
Molecular Weight:419.864
Hs Code.:

Synonyms:8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

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Chemical Property of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

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Technology Process of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

There total 5 articles about 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 87120-67-0
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

: 87120-69-2
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1002/jhet.5570200313

Reference yield:

: 87120-56-7
7-chloro-5-(2-fluorophenyl)-N-hydroxy-3H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

: 87120-69-2
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

2: 73 percent / acetic acid / 1 h / 100 °C

3: 86 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1002/jhet.5570200313

Reference yield:

: 87120-59-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

: 87120-69-2
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylsulfonyl)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / acetic acid / 1 h / 100 °C

2: 86 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / Ambient temperature

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid;
DOI:10.1002/jhet.5570200313