7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

Base Information

Chemical Name:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide
CAS No.:87120-59-0
Molecular Formula:C₁₇H₁₅ClFN₃O₂S
Molecular Weight:379.842
Hs Code.:

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

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Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

There total 3 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 87120-56-7
7-chloro-5-(2-fluorophenyl)-N-hydroxy-3H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

: 87120-59-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; for 2h; Ambient temperature;
DOI:10.1002/jhet.5570200313

Reference yield:

: 76488-36-3
7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

: 87120-59-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 52.5 percent / (CH₃)3COK / tetrahydrofuran / 1 h / Ambient temperature

2: 90 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; potassium tert-butylate; In tetrahydrofuran; ethanol;
DOI:10.1002/jhet.5570200313

Reference yield:

: 60656-76-0
7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide

: 87120-59-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / NaNO₂ / acetic acid / 1) 70 deg C, 10 min.; 2) room temp., 0.5 h

2: 52.5 percent / (CH₃)3COK / tetrahydrofuran / 1 h / Ambient temperature

3: 90 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; potassium tert-butylate; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1002/jhet.5570200313