6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

Base Information

Chemical Name:6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide
CAS No.:857355-33-0
Molecular Formula:C₁₇H₁₆ClN₃O₂
Molecular Weight:329.786
Hs Code.:

Synonyms:6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

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Technology Process of 6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

There total 2 articles about 6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 623155-19-1
3-amino-N-cyclopropyl-4-methylbenzamide

: 857355-33-0
6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 857355-33-0
6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

Guidance literature:

Reference yield: 26.0%

: 586-98-1
2-Hydroxymethylpyridine

: 857355-33-0
6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide

: N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-6-(pyridin-2-ylmethoxy)nicotinamide

Guidance literature:: 2-Hydroxymethylpyridine; With sodium hydride; for 0.166667h;

6-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}nicotinamide; With copper(l) iodide; In 2,4,6-trimethyl-pyridine; at 20 - 100 ℃; for 4.5h;