-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

Base Information

Chemical Name:-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene
CAS No.:145668-31-1
Molecular Formula:C₂₀H₃₆O₃Si
Molecular Weight:352.59
Hs Code.:

<R-(R*)>-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

Synonyms:-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

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Chemical Property of -1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

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Technology Process of -1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

There total 4 articles about -1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 64-19-7,77671-22-8
acetic acid

: 145668-30-0
-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

: tert-Butyl-dimethyl-[(E)-4-((R)-4-methyl-cyclohex-1-enyl)-2-methylene-but-3-enyloxy]-silane

: 145668-31-1
-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

Guidance literature:: With pyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 5h; -45 deg C to 0 deg C;
DOI:10.1021/jo00056a013

Reference yield:

: 18173-64-3
tert-butyldimethylsilanol

: 145668-31-1
-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, r.t., 30 min, 2.) 55-60 deg C, 23 h

2: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

3: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

4: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane;
DOI:10.1021/jo00056a013

Reference yield:

: 145668-28-6
2-(tert-butyldimethylsilyloxy)methyl-3-chloroprop-1-ene

: 145668-31-1
-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

2: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

3: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane;
DOI:10.1021/jo00056a013