tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

Base Information

Chemical Name:tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate
CAS No.:944088-85-1
Molecular Formula:C₁₆H₂₂ClN₃O₉S
Molecular Weight:467.884
Hs Code.:

Synonyms:tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

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Chemical Property of tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

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Technology Process of tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

There total 3 articles about tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 944088-72-6
tert-butyl 2-[(2-hydroxyethyl)(2-chloroethyl)amino]-3,5-dinitrobenzoate

: 7143-01-3
Methanesulfonic anhydride

: 944088-85-1
tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

Guidance literature:: tert-butyl 2-[(2-hydroxyethyl)(2-chloroethyl)amino]-3,5-dinitrobenzoate; Methanesulfonic anhydride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; for 0.5h;

Reference yield: 89.0%

: 944088-72-6
tert-butyl 2-[(2-hydroxyethyl)(2-chloroethyl)amino]-3,5-dinitrobenzoate

: 124-63-0
methanesulfonyl chloride

: 944088-85-1
tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tet.2007.04.044

Reference yield:

: 87363-66-4
tert-butyl 2-chloro-3,5-dinitrobenzoate

: 944088-85-1
tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / LiCl / dimethylformamide / cooling

2: 89 percent / Et₃N / CH₂Cl₂ / 0 °C

With triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.04.044