(4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Base Information

• Chemical Name: (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide
• CAS No.: 172794-69-3
• Molecular Formula: C₁₆H₂₁BrN₂O₄
• Molecular Weight: 385.258
• Mol file: 172794-69-3.mol

Synonyms:(4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Chemical Property of (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide

There total 3 articles about (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

dimethyl amine (124-40-3) + (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester (172794-68-2) → (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide (172794-69-3)

Guidance literature:

In ethanol; for 48h; Ambient temperature;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

Reference yield:

2-(2-bromophenyl)acetaldehyde dimethyl acetal (112396-13-1) → (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide (172794-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.3 percent / p-toluenesulfonic acid, mol. sieves (4 Angstroem) / toluene / 72 h / Heating

2: 92 percent / ethanol / 48 h / Ambient temperature

With 4 A molecular sieve; toluene-4-sulfonic acid; In ethanol; toluene;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

Reference yield:

1-bromo-2-(2-methoxyethenyl)benzene (130089-19-9,130089-23-5,59436-11-2) → (4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide (172794-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.7 percent / p-toluenesulfonic acid, mol. sieves (4 Angstroem) / toluene / 72 h / Heating

2: 92 percent / ethanol / 48 h / Ambient temperature

With 4 A molecular sieve; toluene-4-sulfonic acid; In ethanol; toluene;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

upstream raw materials:

dimethyl amine

(4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

2-(2-bromophenyl)acetaldehyde dimethyl acetal

1-bromo-2-(2-methoxyethenyl)benzene