5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

Base Information

Chemical Name:5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid
CAS No.:1336982-56-9
Molecular Formula:C₂₀H₁₅Cl₂NO₆S₃
Molecular Weight:532.446
Hs Code.:

Synonyms:5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

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Chemical Property of 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

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Technology Process of 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

There total 5 articles about 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1336982-58-1
methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

: 1336982-56-9
5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; Inert atmosphere;
DOI:10.1021/jm2003766

Reference yield:

: 251096-84-1
3-(3,4-dichlorobenzylthio)thiophene-2-carboxylic acid

: 1336982-56-9
5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 25 °C / Inert atmosphere

2: water; lithium hydroxide / methanol / Inert atmosphere

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2003766

Reference yield:

: 90033-62-8
3-Mercaptothiophene-2-carboxylic acid

: 1336982-56-9
5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 25 °C / Inert atmosphere

3: water; lithium hydroxide / methanol / Inert atmosphere

With dmap; water; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm2003766