methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

Base Information

Chemical Name:methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate
CAS No.:1336982-58-1
Molecular Formula:C₂₁H₁₇Cl₂NO₆S₃
Molecular Weight:546.473
Hs Code.:

Synonyms:methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

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Chemical Property of methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

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Technology Process of methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

There total 4 articles about methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 251096-84-1
3-(3,4-dichlorobenzylthio)thiophene-2-carboxylic acid

: 33045-52-2
methyl 2-methoxy-5-sulfamoyl-benzoate

: 1336982-58-1
methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm2003766

Reference yield:

: 90033-62-8
3-Mercaptothiophene-2-carboxylic acid

: 1336982-58-1
methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 25 °C / Inert atmosphere

With dmap; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm2003766

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1336982-58-1
methyl 5-(N-(3-(3,4-dichlorobenzylthio)thiophene-2-carbonyl)sulfamoyl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

1.3: 60 - 70 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 2 h / Reflux; Inert atmosphere

3.1: sodium methylate / methanol; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 25 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm2003766