((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid

Base Information

• Chemical Name: ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid
• CAS No.: 202918-99-8
• Molecular Formula: C₁₃H₁₂N₂O₄S
• Molecular Weight: 292.315
• Mol file: 202918-99-8.mol

Synonyms:((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid

Chemical Property of ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid

There total 1 articles about ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one (35500-75-5) + bromoacetic acid (79-08-3) → ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid (202918-99-8)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol; N,N-dimethyl-formamide; 1.) -30 deg C, 15 min, 2.) 0 deg C, 1 h, 3.) 20 deg C, 2 h;

Reference yield: 55.0%

Chloromethyl pivalate (18997-19-8) + ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid (202918-99-8) → 2,2-Dimethyl-propionic acid 2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetoxymethyl ester

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 44.0%

1,1,1-trichloroethanol (115-20-8) + ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid (202918-99-8) → ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid 2,2,2-trichloro-ethyl ester (202919-23-1)

Guidance literature:

With N,N-diethyl-2-propynylamine; In dichloromethane; for 3h; -60 deg C -> room temperature;

upstream raw materials:

(1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one

bromoacetic acid

Downstream raw materials:

((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid 2,2,2-trichloro-ethyl ester

((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

[(2R,3R)-2-Mercapto-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 2,2,2-trichloro-ethyl ester

[(2R,3R)-2-Mercapto-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester