2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

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Chemical Name:2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one
CAS No.:1093857-57-8
Molecular Formula:C₂₈H₂₆F₅N₅O₄S
Molecular Weight:623.604
Hs Code.:

2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

Synonyms:2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

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Chemical Property of 2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

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Technology Process of 2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

There total 8 articles about 2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1010800-90-4
6-(2,3-difluoro-4-hydroxyphenyl)-4,5-dihydropyridazin-3(2H)-one

: 1093858-00-4
1-(4-bromobutyl)-3-(4-methoxy-2-(trifluoromethyl)benzo[d]thiazol-7-yl)-4,4-dimethyl-1H-pyrazol-5(4H)-one

: 1093857-57-8
2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield:

: 6418-38-8
2,3-difluorophenol

: 1093857-57-8
2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / 18 h / 20 °C

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: N,O-dimethylhydroxylamine*hydrochloride; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 4 h / 0 - 20 °C

3.2: 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 3 h / 0 - 20 °C / Inert atmosphere

4.3: 2.5 h / Reflux

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; 1H-imidazole; n-butyllithium; N,O-dimethylhydroxylamine*hydrochloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield:

: 1010800-88-0
2,3-difluoro-4-((triisopropylsilyl)oxy)benzoic acid

: 1093857-57-8
2-[4-(2,3-Difluoro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-dimethylhydroxylamine*hydrochloride; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 4 h / 0 - 20 °C

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

2.3: 2.5 h / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With N,O-dimethylhydroxylamine*hydrochloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.121