Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

Base Information

Chemical Name:Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide
CAS No.:1607465-12-2
Molecular Formula:C₃₃H₄₅N₇O₇S
Molecular Weight:683.829
Hs Code.:

Synonyms:Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

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Chemical Property of Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

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Technology Process of Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

There total 4 articles about Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1607465-09-7
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide trifluoroacetate

: 20866-46-0
N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine

: 1607465-12-2
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

Guidance literature:: With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201303664

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 1607465-12-2
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 3 h / Reflux

2: dichloromethane / 24 h / 20 °C

3: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; 2-chloro-1-methyl-pyridinium iodide; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664

Reference yield:

: 1607465-03-1
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

: 1607465-12-2
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C

2: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664