N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

Base Information

Chemical Name:N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide
CAS No.:1607465-03-1
Molecular Formula:C₂₂H₃₀N₄O₄S
Molecular Weight:446.571
Hs Code.:

Synonyms:N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

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Technology Process of N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

There total 1 articles about N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1607465-03-1
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 3h; Reflux;
DOI:10.1002/chem.201303664

Reference yield: 99.0%

: 1607465-03-1
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

: 76-05-1
trifluoroacetic acid

: 1607465-09-7
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/chem.201303664

Reference yield:

: 1607465-03-1
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-6-aminohexanamide

: 1607465-12-2
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-6-aminohexanamide]histidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C

2: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664