Technology Process of 2-O-(myo-inositol-2-phosphoryl)-L-ascorbic acid
There total 9 articles about 2-O-(myo-inositol-2-phosphoryl)-L-ascorbic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-O-benzyl-5,6-O-isopropylidene-2-O-(1,3,4,5,6-penta-O-benzyl-myo-inositol-2-benzylphosphoryl)-L-ascorbic acid;
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 1.5h;
under 760 Torr;
DOI:10.1016/0008-6215(96)00043-2
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: p-TsOH / dimethylformamide; toluene / 10 h / 122 - 136 °C
1.2: 98 percent / p-TsOH; EtOH / 48 h / 20 °C
2.1: KOH / 2 h / 115 - 131 °C
3.1: AcOH; water / 4 h / 80 - 105 °C
4.1: 79 percent / NaOH / benzene / 5 h / Heating
5.1: 1H-tetrazole / CH2Cl2 / 96 h / 20 °C
6.1: 2.5 g / m-chloroperoxybenzoic acid / CH2Cl2 / 1 h / 0 - 20 °C
7.1: HCl; H2O / tetrahydrofuran / 1 h / 20 °C
7.2: 88 percent / hydrogen / Pd/C / methanol / 1.5 h / 20 °C / 760 Torr
With
1H-tetrazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; water; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
1.1: Condensation / 1.2: alcoholysis / 2.1: Alkylation / 3.1: Hydrolysis / 4.1: Alkylation / 5.1: Condensation / 6.1: Oxidation / 7.1: Hydrolysis / 7.2: Hydrogenolysis;
DOI:10.1016/0008-6215(96)00043-2
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: KOH / 2 h / 115 - 131 °C
2.1: AcOH; water / 4 h / 80 - 105 °C
3.1: 79 percent / NaOH / benzene / 5 h / Heating
4.1: 1H-tetrazole / CH2Cl2 / 96 h / 20 °C
5.1: 2.5 g / m-chloroperoxybenzoic acid / CH2Cl2 / 1 h / 0 - 20 °C
6.1: HCl; H2O / tetrahydrofuran / 1 h / 20 °C
6.2: 88 percent / hydrogen / Pd/C / methanol / 1.5 h / 20 °C / 760 Torr
With
1H-tetrazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; water; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; benzene;
1.1: Alkylation / 2.1: Hydrolysis / 3.1: Alkylation / 4.1: Condensation / 5.1: Oxidation / 6.1: Hydrolysis / 6.2: Hydrogenolysis;
DOI:10.1016/0008-6215(96)00043-2
