1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione
• CAS No.: 448896-41-1
• Molecular Formula: C₄₁H₄₈N₂O₅Si₂
• Molecular Weight: 705.014
• Mol file: 448896-41-1.mol

Synonyms:1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

There total 9 articles about 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (287933-76-0) → 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (448896-41-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 23h;

DOI:10.1007/s007060200024

Reference yield:

tert-Butyl-[(R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane → 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (448896-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 7 percent / CDCl₃ / 36 h / 20 °C

2: 81 percent / imidazole / dimethylformamide / 23 h / 20 °C

With 1H-imidazole; In chloroform-d1; N,N-dimethyl-formamide;

DOI:10.1007/s007060200024

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (448896-41-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / Et₃N; DMAP

2: 100 percent / 5 percent Na/Hg; NaH₂PO₄ / methanol; tetrahydrofuran

3: dimethyl dioxirane / CH₂Cl₂

4: 75 percent / HCl / CDCl₃; H₂O

5: ImH / dimethylformamide

With 1H-imidazole; hydrogenchloride; dmap; sodium dihydrogenphosphate; sodium amalgam; 3,3-dimethyldioxirane; triethylamine; In tetrahydrofuran; methanol; chloroform-d1; dichloromethane; water; N,N-dimethyl-formamide; 1: Silylation / 2: Reduction / 3: Epoxidation / 4: Alkylation / 5: Silylation;

DOI:10.1016/S0040-4039(00)00467-6

upstream raw materials:

tert-butylchlorodiphenylsilane

1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

(S)-2-((E)-2-Benzenesulfonyl-vinyloxymethyl)-oxirane

Downstream raw materials:

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone

4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone