4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

Base Information

• Chemical Name: 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone
• CAS No.: 448896-42-2
• Molecular Formula: C₄₁H₄₉N₃O₄Si₂
• Molecular Weight: 704.029
• Mol file: 448896-42-2.mol

Synonyms:4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

Chemical Property of 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

There total 11 articles about 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone (287933-77-1) → 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone (448896-42-2)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 20 ℃; for 72h;

DOI:10.1007/s007060200024

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone (448896-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / imidazole / dimethylformamide / 23 h / 20 °C

2: 93 percent / 4-chlorophenyl dichlorophosphate / pyridine / 28 h / 20 °C

3: 93 percent / sat. aq. NH₃ / dioxane / 72 h / 20 °C

With 1H-imidazole; ammonium hydroxide; 4-chlorophenylphosphorodichloridate; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1007/s007060200024

Reference yield:

1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (287933-76-0) → 4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone (448896-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / imidazole / dimethylformamide / 23 h / 20 °C

2: 93 percent / 4-chlorophenyl dichlorophosphate / pyridine / 28 h / 20 °C

3: 93 percent / sat. aq. NH₃ / dioxane / 72 h / 20 °C

With 1H-imidazole; ammonium hydroxide; 4-chlorophenylphosphorodichloridate; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1007/s007060200024

upstream raw materials:

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone

tert-butylchlorodiphenylsilane

1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione