1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione
• CAS No.: 287933-76-0
• Molecular Formula: C₂₅H₃₀N₂O₅Si
• Molecular Weight: 466.609

Synonyms:1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Technology Process of 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

There total 9 articles about 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (448896-40-0) → 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (287933-76-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 0.5h;

DOI:10.1007/s007060200024

Reference yield: 75.0%

tert-Butyl-[(1R,4R,5R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane (287933-73-7) + O,O'-bis-(trimethylsilyl)uracil (10457-14-4) → 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (287933-76-0)

Guidance literature:

With hydrogenchloride; In chloroform-d1; water;

DOI:10.1016/S0040-4039(00)00467-6

Reference yield: 54.0%

1,3-bis(trimethylsilyl)uracil (3442-82-8) + tert-Butyl-[(R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane → 1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione (287933-76-0) + 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (448896-40-0)

Guidance literature:

In chloroform-d1; at 20 ℃; for 36h;

DOI:10.1007/s007060200024

upstream raw materials:

tert-Butyl-[(1R,4R,5R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane

O,O'-bis-(trimethylsilyl)uracil

1,3-bis(trimethylsilyl)uracil

1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Downstream raw materials:

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone

4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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