(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

Base Information

Chemical Name:(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine
CAS No.:1422192-38-8
Molecular Formula:C₂₀H₂₂N₄O₂S
Molecular Weight:382.486
Hs Code.:

Synonyms:(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

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Chemical Property of (Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

Chemical Property:

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Technology Process of (Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

There total 12 articles about (Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₈N₄

: 98-09-9
benzenesulfonyl chloride

: 1422192-38-8
(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

Guidance literature:: C₁₄H₁₈N₄; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

benzenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: 98303-20-9
1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

: 1422192-38-8
(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 15 h / 20 °C / Inert atmosphere

2.1: diethyl ether / 1 h / 0 °C / Inert atmosphere

3.1: potassium tert-butylate / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: acetic acid / diethyl ether / 24 h / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 15 h / Inert atmosphere

6.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

7.1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

9.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

9.2: 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2-Methyl-2-nitropropane; trimethylsilylazide; potassium tert-butylate; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile; 6.1: |Suzuki Coupling;
DOI:10.1021/ol400137q

Reference yield:

: 4043-87-2,83680-83-5
pipecolic Acid

: 1422192-38-8
(Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / 15 h / 0 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Inert atmosphere

3.1: diethyl ether / 1 h / 0 °C / Inert atmosphere

4.1: potassium tert-butylate / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: acetic acid / diethyl ether / 24 h / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

6.2: 15 h / Inert atmosphere

7.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

8.1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

10.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

10.2: 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2-Methyl-2-nitropropane; trimethylsilylazide; potassium tert-butylate; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile; 7.1: |Suzuki Coupling;
DOI:10.1021/ol400137q