1-BOC-2-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE

Base Information

• Chemical Name: 1-BOC-2-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE
• CAS No.: 211310-10-0
• Molecular Formula: C13H24 N2 O4
• Molecular Weight: 272.34
• Hs Code.: 2933399090
• Mol file: 211310-10-0.mol

Synonyms:1,1-Dimethylethyl2-(N-methoxy-N-methylcarbamoyl)piperidine-1-carboxylate;1-[tert-Butyloxycarbonyl]-2-[N-methoxy-N-methylcarbamoyl]piperidine

Chemical Property of 1-BOC-2-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE

Chemical Property:

• PSA: 59.08000
• LogP: 1.73370

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-2-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE

There total 6 articles about 1-BOC-2-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) → 2-(methoxy-N-methylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (211310-10-0)

Guidance literature:

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

O,N-dimethyl-hydroxylamine hydrochloride; In dichloromethane; for 3h;

DOI:10.1039/d1ob02304g

Reference yield: 84.0%

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) + N,0-dimethylhydroxylamine (1117-97-1) → 2-(methoxy-N-methylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (211310-10-0)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃; for 20.5h;

Reference yield:

hydrochloric acid, water, a saturated aqueous sodium hydrogen carbonate + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) → 2-(methoxy-N-methylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (211310-10-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

di-tert-butyl dicarbonate

pipecolic Acid

Downstream raw materials:

tert-butyl 2-formylpiperidine-1-carboxylate

1,1-dimethylethyl 2-benzoyl-1-piperidinecarboxylate

1-tert-butoxycarbonyl-2-acetylpiperidine

hexahydroindolizin-7(1H)-one

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