(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane
CAS No.:1372785-75-5
Molecular Formula:C₃₂H₄₀O₃Si
Molecular Weight:500.753
Hs Code.:

Synonyms:(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Suppliers and Price of (2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

There total 17 articles about (2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1384898-60-5
(2R,5S,6R)-5-(benzyloxy)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-tetrahydro-2H-pyran-2-carbaldehyde

: 19493-09-5
Methylenetriphenylphosphorane

: 1372785-75-5
(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2012.02.009

Reference yield:

: 1372785-69-7
(3R,4S)-4-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)oct-7-en-3-yl 4-nitrobenzoate

: 1372785-75-5
(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol; potassium carbonate / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 5 h / 0 - 20 °C

3.1: ozone / dichloromethane / 0.25 h / -78 °C

3.2: -78 °C

4.1: benzene / 2 h / Reflux

5.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / 0 °C

5.2: 1 h / 20 °C

6.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C

7.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide / dichloromethane / 6 h / -20 °C / Molecular sieve

7.2: 3 h / -20 - 20 °C

8.1: sodium periodate / water; acetone / 0.5 h / 20 °C

9.1: tetrahydrofuran / 1 h / 20 °C

With titanium(IV) isopropylate; methanol; sodium periodate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide; water; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ozone; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; water; acetone; benzene; 4.1: Wittig reaction / 7.1: Sharpless asymmetric epoxidation / 9.1: Wittig reaction;
DOI:10.1016/j.tetasy.2012.02.009

Reference yield:

: 1372785-68-6
(3S,4S)-4-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)oct-7-en-3-ol

: 1372785-75-5
(2-((2R,3S,6R)-3-(benzyloxy)-6-vinyl-tetrahydro-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 10 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: methanol; potassium carbonate / 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 5 h / 0 - 20 °C

4.1: ozone / dichloromethane / 0.25 h / -78 °C

4.2: -78 °C

5.1: benzene / 2 h / Reflux

6.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / 0 °C

6.2: 1 h / 20 °C

7.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C

8.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide / dichloromethane / 6 h / -20 °C / Molecular sieve

8.2: 3 h / -20 - 20 °C

9.1: sodium periodate / water; acetone / 0.5 h / 20 °C

10.1: tetrahydrofuran / 1 h / 20 °C

With titanium(IV) isopropylate; methanol; sodium periodate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide; di-isopropyl azodicarboxylate; water; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ozone; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; water; acetone; benzene; 1.1: Mitsunobu reaction / 5.1: Wittig reaction / 8.1: Sharpless asymmetric epoxidation / 10.1: Wittig reaction;
DOI:10.1016/j.tetasy.2012.02.009