tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

Base Information

Chemical Name:tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate
CAS No.:1202411-51-5
Molecular Formula:C₁₇H₃₀N₂O₄
Molecular Weight:326.436
Hs Code.:

Synonyms:tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

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Chemical Property of tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

Chemical Property:

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Technology Process of tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

There total 1 articles about tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 222530-39-4,218772-92-0,222530-33-8
(1R,3S)-3-(tert-butoxycarbonylamino)aminocyclohexanecarboxylic acid

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1202411-51-5
tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

Guidance literature:: (1R,3S)-3-(tert-butoxycarbonylamino)aminocyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

4-HYDROXYPIPERIDINE; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1202411-51-5
tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

: 1-{[(1R,3S)-3-aminocyclohexyl]carbonyl}piperidin-4-ol hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 1202411-51-5
tert-butyl {(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}carbamate

: 1202410-55-6
6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.2: 18 h / 20 °C

With hydrogenchloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;