6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

Base Information

Chemical Name:6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide
CAS No.:1202410-55-6
Molecular Formula:C₂₄H₂₈FN₃O₃
Molecular Weight:425.503
Hs Code.:

Synonyms:6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

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Chemical Property of 6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

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Technology Process of 6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

There total 6 articles about 6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 582325-22-2
6-(3-fluorophenyl)-3-pyridinecarboxylic acid

: 1-{[(1R,3S)-3-aminocyclohexyl]carbonyl}piperidin-4-ol hydrochloride salt

: 1202410-55-6
6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

Guidance literature:: 6-(3-fluorophenyl)-3-pyridinecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

1-{[(1R,3S)-3-aminocyclohexyl]carbonyl}piperidin-4-ol hydrochloride salt; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1202410-55-6
6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 20 h / Reflux

1.2: pH 3

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.2: 18 h / 20 °C

With tetrabutylammomium bromide; potassium carbonate; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1202410-55-6
6-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-hydroxypiperidin-1-yl)carbonyl]cyclohexyl}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 20 h / Reflux

1.2: pH 3

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.2: 18 h / 20 °C

With tetrabutylammomium bromide; potassium carbonate; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene;