(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

Base Information

Chemical Name:(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone
CAS No.:123054-08-0
Molecular Formula:C₁₉H₂₈N₂O₃
Molecular Weight:332.443
Hs Code.:

Synonyms:(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

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Technology Process of (1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

There total 7 articles about (1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75-44-5
phosgene

: 123054-03-5
Acetic acid (S)-2-((1S,2S)-2-amino-1-ethyl-3-phenyl-propylamino)-3-methyl-butyl ester

: 123054-08-0
(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

Guidance literature:: With triethylamine; In dichloromethane; toluene; at -20 ℃; for 0.5h;
DOI:10.1021/jo00284a032

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 123054-08-0
(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / acetic acid (pH ca. 6), sodium cyanoborohydride / methanol / 16 h / Ambient temperature

2: 75 percent / neat (no solvent) / 16 h / 50 °C

3: diethyl ether / 1.5 h / 0 - 20 °C

4: 82 percent / Et₃N / tetrahydrofuran / 3 h / 0 - 20 °C

5: 37 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate / 48 h / 3040 Torr / Ambient temperature

6: 78 percent / Et₃N / CH₂Cl₂; toluene / 0.5 h / -20 °C

With hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo00284a032

Reference yield:

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 123054-08-0
(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / neat (no solvent) / 16 h / 50 °C

2: diethyl ether / 1.5 h / 0 - 20 °C

3: 82 percent / Et₃N / tetrahydrofuran / 3 h / 0 - 20 °C

4: 37 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate / 48 h / 3040 Torr / Ambient temperature

5: 78 percent / Et₃N / CH₂Cl₂; toluene / 0.5 h / -20 °C

With hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo00284a032