Technology Process of (1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone
There total 7 articles about (1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane; toluene;
at -20 ℃;
for 0.5h;
DOI:10.1021/jo00284a032
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 79 percent / acetic acid (pH ca. 6), sodium cyanoborohydride / methanol / 16 h / Ambient temperature
2: 75 percent / neat (no solvent) / 16 h / 50 °C
3: diethyl ether / 1.5 h / 0 - 20 °C
4: 82 percent / Et3N / tetrahydrofuran / 3 h / 0 - 20 °C
5: 37 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 48 h / 3040 Torr / Ambient temperature
6: 78 percent / Et3N / CH2Cl2; toluene / 0.5 h / -20 °C
With
hydrogen; sodium cyanoborohydride; acetic acid; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo00284a032
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / neat (no solvent) / 16 h / 50 °C
2: diethyl ether / 1.5 h / 0 - 20 °C
3: 82 percent / Et3N / tetrahydrofuran / 3 h / 0 - 20 °C
4: 37 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 48 h / 3040 Torr / Ambient temperature
5: 78 percent / Et3N / CH2Cl2; toluene / 0.5 h / -20 °C
With
hydrogen; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo00284a032
