tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate
• CAS No.: 925920-88-3
• Molecular Formula: C₁₈H₂₅N₃O₅
• Molecular Weight: 363.414
• Mol file: 925920-88-3.mol

Synonyms:tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate (925920-88-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

4-nitro-benzoyl chloride (122-04-3) + 4-methylamino-piperidine-1-carboxylic acid tert-butyl ester (147539-41-1) → tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate (925920-88-3)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

4-nitro-benzoic acid (62-23-7) → tert-butyl 4-(N-methyl-4-nitrobenzoylamino)piperidine-1-carboxylate (925920-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 25 °C

2: triethylamine / dichloromethane / 1 h / 25 °C

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2020.115354

upstream raw materials:

4-nitro-benzoyl chloride

4-methylamino-piperidine-1-carboxylic acid tert-butyl ester

4-nitro-benzoic acid

N-tert-butyloxycarbonylpiperidin-4-one