[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

Base Information

Chemical Name:[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol
CAS No.:643747-88-0
Molecular Formula:C₁₁H₆Cl₃F₃N₂O₂
Molecular Weight:361.535
Hs Code.:

Synonyms:[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

Chemical Property:

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Technology Process of [2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

There total 3 articles about [2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 643747-87-9
2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester

: 643747-88-0
[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2003.08.055

Reference yield:

: 20098-48-0
3,4,5-trichloronitrobenzen

: 643747-88-0
[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: SnCl₂ / ethanol / 1 h / Heating

3: 35 percent / CuCl₂; tBuONO / acetonitrile / 1 h / 65 °C

4: 18 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; tert.-butylnitrite; potassium carbonate; tin(ll) chloride; copper dichloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2003.08.055

Reference yield:

: 135026-17-4
ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate

: 643747-88-0
[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: SnCl₂ / ethanol / 1 h / Heating

3: 35 percent / CuCl₂; tBuONO / acetonitrile / 1 h / 65 °C

4: 18 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; tert.-butylnitrite; potassium carbonate; tin(ll) chloride; copper dichloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2003.08.055