2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 135026-17-4
• Molecular Formula: C7H7F3N2O3
• Molecular Weight: 224.139
• Hs Code.: 2934999090
• Mol file: 135026-17-4.mol

Synonyms:2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000802mmHg at 25°C
• Melting Point: 188-190°
• Refractive Index: 1.455
• Boiling Point: 305.8°C at 760 mmHg
• PKA: -0.03±0.10(Predicted)
• Flash Point: 138.8°C
• PSA: 78.35000
• Density: 1.440
• LogP: 2.03350
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Amino-4-(trifluoromethyl)oxazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate (363-58-6) + urea (57-13-6) → ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (135026-17-4)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 72h;

Reference yield:

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate (363-58-6) → ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (135026-17-4)

Guidance literature:

With urea; In N-methyl-acetamide; chloroform;

Reference yield:

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (135026-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0 - 20 °C

2: ethanol / Reflux

With thionyl chloride; In ethanol; dichloromethane;

upstream raw materials:

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

urea

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate

ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate

2-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-butyrylamino}-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester

2-(4-amino-2,6-dichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester