2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

Base Information

Chemical Name:2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde
CAS No.:643747-89-1
Molecular Formula:C₁₁H₄Cl₃F₃N₂O₂
Molecular Weight:359.519
Hs Code.:

Synonyms:2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

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Chemical Property of 2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

Chemical Property:

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Technology Process of 2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

There total 4 articles about 2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 643747-88-0
[2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazol-5-yl]-methanol

: 643747-89-1
2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2003.08.055

Reference yield:

: 20098-48-0
3,4,5-trichloronitrobenzen

: 643747-89-1
2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: SnCl₂ / ethanol / 1 h / Heating

3: 35 percent / CuCl₂; tBuONO / acetonitrile / 1 h / 65 °C

4: 18 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

5: 59 percent / Dess-Martin reagent / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; tert.-butylnitrite; potassium carbonate; Dess-Martin periodane; tin(ll) chloride; copper dichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 5: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2003.08.055

Reference yield:

: 135026-17-4
ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate

: 643747-89-1
2-(2,4,6-trichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: SnCl₂ / ethanol / 1 h / Heating

3: 35 percent / CuCl₂; tBuONO / acetonitrile / 1 h / 65 °C

4: 18 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

5: 59 percent / Dess-Martin reagent / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; tert.-butylnitrite; potassium carbonate; Dess-Martin periodane; tin(ll) chloride; copper dichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 5: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2003.08.055