ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Base Information

Chemical Name:ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate
CAS No.:1350468-90-4
Molecular Formula:C₃₈H₃₄F₃N₃O₇
Molecular Weight:701.699
Hs Code.:

ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Synonyms:ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

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Chemical Property of ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

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Technology Process of ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

There total 16 articles about ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 594844-27-6
2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetic acid

: 1350468-50-6
ethyl (R)-1-(hydroxymethyl)-2-methyl-3-oxoisoindoline-1-carboxylate

: 1350468-90-4
ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1350468-86-8
dimethyl [3-(dimethylcarbamoyl)-4-nitrophenyl]malonate

: 1350468-90-4
ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; water / 3 h / Reflux

2: acetyl chloride / 3 h / 0 - 20 °C

3: hydrogen / 5%-palladium/activated carbon / toluene; tetrahydrofuran / 20 °C / 37503.8 Torr

4: triethylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

5: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With hydrogenchloride; dmap; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride; lithium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 84392-17-6
4'-(trifluoromethyl)-2-biphenylcarboxylic acid

: 1350468-90-4
ethyl 1R-({2-[3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 2.5 h / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With dmap; oxalyl dichloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;